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For these cases, detection is based on identifying the parent drug or metabolite(s) or both. Identification consists of obtaining the chromatographic retention time or relative retention time and the mass spectrum of the substance and showing that the (relative) retention time and spectrum match that of a reference compound. The peaks corresponding to boldenone (17β-hydroxyandrosta-1,4-dien-3-one) and two major metabolites (17β-hydroxy-5β-androst-1-en-3-one and 3α-hydroxy-5β-androst-1-en-17-one) are emphasized (3 ). The spectra of these three peaks matched those of known (reference) compounds (data not shown). In this case the analysis identified not only a xenobiotic steroid but also two metabolites of the steroid. Thus the amount of analytical information obtained in this analysis is far beyond simple identification of a single substance indeed, this analysis is helpful in responding to assertions that the sample might have been fortified, because the finding of metabolites is legal evidence that the individual who submitted the urine ingested the substance.

 

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April 2011 - The Swiss-based Court of Arbitration for Sport appoints a panel to try 2010 Tour de France winner Alberto Contador's doping case. If Contador is found guilty, he could lose his title and be banned for two years. April 13, 2011 - Bonds is convicted of one count of obstruction of justice, bodybuilding supplements. A mistrial is declared on three counts of perjury after jurors report they can't reach an agreement, bodybuilding supplements. July 6, 2011 - Jury selection begins in the Clemens' trial. Biomarker characteristics A biomarker should possess key characteristics and qualities, which will depend upon its intended use (Aronson, 2005 LaBaer, 2005 ). A biomarker must be accurate, sensitive and specific. The biomarker should be altered in the relevant disease and be able to discriminate between diseased and control populations. It should also be possible to quantify the biomarker reliably and reproducibly. For diagnostic purposes biomarkers should ideally be obtained from readily accessible body fluids in animals such as blood plasma, urine, sweat and saliva or other accessible materials such as hair and feces. The identification and quantification of biomarkers also provides an opportunity to accurately assess the clinical responses to therapy and guide decisions on treatment programs.

 

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